Migen L. Osorio was born on 17 March 1945 in Cebu. She has an AB English, from the UP, 1967 and AB, Fine Arts, Philippine Women's University. She was a fellow at the Silliman and UP Writers Workshops. She was also a graduate student in psychology at the Ateneo de Manila University. Her novel, Come Down, Louella, was serialized in Fina magazine from 1980 to 1982.
Osorio is also a painter and has had three solo exhibits.